![]() Its Press, originating in 1933, is the largest of the Laboratory's fiveĮducation divisions and is a publisher of books, journals, and electronic media for scientists, students, and the general ![]() Sciences and has a variety of educational programs. The journal also features exciting gene discoveries and reports of cutting-edgeĬomputational biology and high-throughput methodologies.Ībout Cold Spring Harbor Laboratory Press:Ĭold Spring Harbor Laboratory is a private, nonprofit institution in New York that conducts research in cancer and other life Proteomics, epigenomics, and systems biology. Among the topics considered by the journalĪre genome structure and function, comparative genomics, molecular evolution, genome-scale quantitative and population genetics, ![]() Into the genome biology of all organisms, including advances in genomic medicine. Launched in 1995, Genome Research ( is an international, continuously published, peer-reviewed journal that focuses on research that provides novel insights Peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 millionĬlonotypes. Exhaustive T-cell repertoire sequencing of human Warren RL, Freeman JD, Zeng T, Choe G, Munro S, Moore R, Webb JR, Holt RA. The manuscript will be published online ahead of print on February 24, 2011. The authors are available for more information by contacting Cher Sawchuk, Communications Leader at the BC Cancer Agency This work was supported by the Canadian Institutes of Health Research, Genome Canada, and Genome British Columbia. Scientists from the British Columbia Cancer Agency (Vancouver, British Columbia, Canada) and Simon Fraser University (Burnaby,īritish Columbia, Canada) contributed to this study. Or organ transplantation, and furthermore, may assist in the development of new vaccines. Would be able to then recognize how the repertoire is disturbed in cases of immune challenge, such as infectious disease In recognizing specific types of infections or mutations,” said Holt.īy cataloging the baseline diversity of the immune repertoire in a healthy individual, Holt explained that future studies “This shows that certain sequences are more favored than others, most likely because they are more effective Interestingly, they noted that for sequences that were shared, different gene shuffling events had often generated the same The individual repertoire was then compared to that of two other individuals, showing that only a minority of sequences The group found that some T-cell receptor sequences are common, some are rare, and the repertoire can change over time. Know that although the diversity is very large, it is ultimately limited, and it is measureable.” “This is only part of the diversity that would be present within a person’s entire body,” Holt said, “but now we Is the first to establish that while there is high T-cell diversity in a standard blood sample, it does not give the entire Robert Holt of the BC Cancer Agency and Simon Fraser University, senior author of the report, explained that this study In Canada have identified essentially all T-cell receptor variants in blood samples, identifying more than one million uniqueĭr. Now, using next-generation sequencing technology, researchers To capture the entire range present in an individual sample. While the diversity of sequences in immune cell repertoires has been investigated previously, no study had yet been able Mutations, gene shuffling creates a highly variable and diverse collection of T-cell receptor sequences. To recognize a wide array of potentially infectious agents or cancer-causing Viruses or contain cancer-causing mutations. The first time in a study published online today in Genome Research ( setting the stage for a better understanding of infectious disease, cancer, and immune system disorders.Īdaptive immunity is mediated by T-cells, a white blood cell that identifies and attacks cells that may be infected with Entire T-cell receptor repertoire sequenced revealing extensive and unshared diversityįebru– T-cell receptor diversity in blood samples from healthy individuals has been extensively cataloged for
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